在心房动患者甲状腺疾病的预后影响
Anthi Vasilopoulou1, Vasiliki Patsiou1, Alexandra Bekiaridou2,3
1First Department of Cardiology, School of Medicine, Faculty of Health Sciences, AHEPA University Hospital, Aristotle University of Thessaloniki, St. Kiriakidi 1, 54636, Thessaloniki, Greece.
Heart and vessels
|December 12, 2023
概括
在心房动 (AF) 患者的甲状腺疾病影响结果. 甲状腺功能低下症增加了住院治疗,而异常的甲状腺刺激激素 (TSH) 和三甲状腺素 (T3) 水平与死亡风险有关.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 临床研究 临床研究
背景情况:
- 心房动 (AF) 经常与甲状腺疾病 (THD) 一起发生.
- 了解THD对AF患者临床结果的影响对于风险分层和风险管理至关重要.
- 以前的研究表明存在联系,但与不同THD亚型相关的具体结果需要进一步调查.
研究的目的:
- 调查甲状腺疾病与心房动患者的主要临床结果之间的关联.
- 为了确定特定的甲状腺功能障碍 (甲状腺功能过高,甲状腺功能下降) 是否影响死亡率和住院率.
- 探索甲状腺激素水平 (TSH,T3) 和AF患者的不良事件之间的关系.
主要方法:
- 一个对MISOAC-AF试验 (NCT02941978) 的后期分析,涉及住院AF患者.
- 根据THD病史,患者被分为甲状腺功能障碍症,甲状腺功能障碍症和甲状腺功能障碍症组.
- 考克斯回归模型用于计算所有原因死亡率,心血管死亡和住院病例的危险比率 (HR).
主要成果:
- 甲状腺功能低下症与与甲状腺功能不良的AF患者相比,住院率显著更高 (aHR:1.57).
- 甲状腺刺激激素 (TSH) 水平升高与心血管死亡率 (aHR: 1.03) 和住院病例 (aHR: 1.06) 的增加相关.
- 较低的三甲状腺素 (T3) 水平与较高的全因死亡风险 (aHR:0.51) 和心血管死亡风险 (aHR:0.42) 有关.
结论:
- 在AF患者中,甲状腺功能低下与住院治疗增加有关.
- 甲状腺激素水平异常,特别是TSH升高和T3降低,与心血管和全因死亡率的风险增加有关.
- 这些发现强调了监测甲状腺功能在AF患者的重要性,以潜在地减轻不良的临床结果.
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