适度饮酒对百万退伍军人计划中中风风险的影响
Rebecca J Song1, Martin G Larson2,3, Hugo J Aparicio4,5
1MAVERIC VA Boston Healthcare System, Lafayette City Center, 2 Avenue de Lafayette, Boston, MA, 02111, USA. rsong@bu.edu.
BMC public health
|December 13, 2023
概括
适度饮酒 (每天1-2杯) 与美国退伍军人的缺血性中风风险降低有关. 饮料偏好并没有显著改变中风风险. 需要进一步的研究来证实这些发现.
科学领域:
- 心血管流行病学心血管流行病学
- 酒精研究 酒精研究
- 神经学 神经学
背景情况:
- 关于一般人群中适度饮酒和中风风险的证据不一致.
- 这种关联在美国退伍军人中没有得到充分的研究.
- 特定饮料偏好 (酒,葡萄酒,烈酒) 对中风风险的影响尚不清楚.
研究的目的:
- 研究美国退伍军人中适度饮酒与中风风险之间的关联.
- 为了确定饮料偏好是否影响中风风险.
- 为了检查中风风险,按中风类型分层 (缺血与出血).
主要方法:
- 分析了来自1.85亿323万退伍军人计划参与者的数据.
- 适度饮酒量定义为每天1-2杯酒.
- 饮料偏好定义为来自单一类型 (酒,葡萄酒或烈酒) 的饮料总量的≥50%.
- 使用ICD-9和ICD-10代码识别的中风事件.
- 考克斯的比例危险模型用于统计分析,调整了许多共同变量.
主要成果:
- 适度饮酒 (每天1-2杯) 与总中风风险降低22%,与从未饮酒相比.
- 在缺血性中风 (HR 0.76 [0.65,0.90)) 中观察到类似的保护性关联.
- 没有发现出血性中风风险的统计学上显著差异.
- 根据饮料偏好 (酒,葡萄酒,烈酒) 观察到中风风险没有显著差异.
- 这种保护性关联在之前住院次数较多的个体中似乎减弱.
结论:
- 在美国退伍军人中,适度饮酒与缺血性中风的风险降低有关,但并非出血性中风.
- 饮料偏好似乎没有显著改变这一群体中风风险.
- 健康用户偏见可能有助于观察到的保护性关联.
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