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选择性大动脉 perfusion:这是第一次在人身上进行观察性尸体研究.

Max Marsden^1,2, Jon Barratt^2,3, Helen Donald-Simpson⁴

¹Blizard Institute, The Faculty of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.

Scandinavian journal of trauma, resuscitation and emergency medicine

|December 13, 2023

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选择性大动脉弧 perfusion (SAAP) 是一种新的技术,用于在大动脉手术过程中 perfusing 大脑和心脏. 这项研究表明,SAAP在人类中是可行的,具有冠状动脉进入的潜力.

科学领域:

心血管外科心血管外科
血管内技术血管内技术
医疗设备创新医疗设备创新

背景情况:

选择性大动脉弧 perfusion (SAAP) 是一种新兴的内血管技术,将胸前大动脉封闭与大脑和心脏的体外 perfusion 结合起来.
SAAP显示出治疗冠状动脉缺血导致的出血性休克和心脏骤停的潜力,并得到动物研究的支持.
目前对于SAAP没有人类数据,需要进行可行性研究.

研究的目的:

评估在人类中进行选择性大动脉弧 perfusion (SAAP) 的可行性.
评估SAAP导管在直接进入冠状动脉方面的潜力,使其能够挽救穿皮冠状动脉干预.

主要方法:

一个SAAP导管的原型被插入到下降的大动脉通过大腿部进入 perfused 人类尸体.
光学指导用于导管插入和气球膨胀,以实现大动脉弧 perfusion.
为评估,冠状动脉通过SAAP导管进行了通道.

主要成果:

在四个试验中的两个试验中,成功插入了SAAP导管,并实现了大动脉弧 perfusion.
在一项试验中,SAAP导管证明了左冠状动脉系统的成功导管.
在四个程序尝试中的一个过程中发生了设备故障.

关键词:

心脏骤停是因为心脏停止了.血管内存的血管内存.复苏复苏复苏复苏复苏复苏这就是SAAP的SAAP.创伤是一个创伤.

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结论:

这项使用 perfused cadaveric 模型的研究表明了插入 SAAP 导管并实现 SAAP 的初始可行性和安全性.
传统的内血管技术可用于SAAP导管插入和部署.
该SAAP导管方便进入近道大动脉,使冠状动脉和大脑循环的逆向 perfusion.