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在实验性自身免疫性脑膜炎中以Fe-curcumin纳米酶为媒介的免疫抑制和抗炎症

Zhengxuan Jiang¹, Kun Liang¹, Xiang Gao¹

¹Department of Ophthalmology, The Second Affiliated Hospital, Anhui Medical University, Hefei, 230601, Anhui, P. R. China.

Biomaterials research

|December 13, 2023

概括

一种新的Fe-curcumin纳米酶通过减少炎症和活性氧物种 (ROS) 有效地治疗实验性自身免疫性脑膜炎 (EAU). 这种抗氧化纳米酶显示出作为阿联安全有效的治疗剂的前景.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
免疫学免疫学免疫学

背景情况:

实验性自身免疫性脑膜炎 (EAU) 涉及自身炎症和自身免疫性,由活性氧物种 (ROS) 加剧.
目前用于EAU的激素疗法具有显著的不良影响.
迫切需要更有效,更安全的EAU治疗.

研究的目的:

开发和评估用于治疗EAU的Fe-curcumin纳米酶.
评估纳米酶的抗炎和ROS清除能力.
在EAU模型中确定Fe-curcumin纳米酶的治疗疗效和安全性.

主要方法:

一种Fe-curcumin纳米酶通过与Fe3+协调天然抗氧化剂来合成.
纳米酶特性通过各种实验进行了分析.
在EAU模型大鼠和外周血液单核细胞 (PBMC) 中评估了疗效.

主要成果:

在低度下,Fe-curcumin纳米酶表现出强大的自由基清除作用.
在体外和体内研究表明,治疗组的炎症和ROS水平降低.
关键的炎症性细胞因子 (IFN-γ,IL-17,TNF-α) 被下调,Th1/Th17细胞增殖被抑制,眼部病理状况得到改善.
普鲁士蓝色染色证实了视网膜中纳米酶的存在,没有观察到细胞毒性.

结论:

在阿联,Fe-curcumin纳米酶是一种可行的纳米药物,用于抑制炎症和清除ROS.
该纳米酶显示出作为EAU治疗中临床应用的有前途的治疗剂的潜力.

关键词:

库尔库明是一种黄素.豁免权是一种豁免权.炎症炎症是一种炎症.纳米酶纳米酶是一种纳米酶.排卵管炎排卵管炎是一种

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