针对神经母细胞瘤中的髓状微环境
Marjolein C Stip1, Loes Teeuwen1, Miranda P Dierselhuis2
1Center for Translational Immunology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
Journal of experimental & clinical cancer research : CR
|December 13, 2023
概括
髓状细胞是神经母细胞瘤的关键参与者,经常抑制免疫反应. 重编程这些细胞提供了一个有希望的策略,以提高免疫治疗对这种癌症的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 骨髓状细胞,包括粒细胞和单细胞/巨细胞,在神经母细胞瘤的发展和进展中至关重要.
- 这些细胞形成了一个免疫抑制网络,阻碍了自适应性免疫系统对抗高危神经母细胞瘤的能力.
- 骨髓系衍生抑制细胞 (MDSC) 对这种免疫抑制有显著的贡献.
研究的目的:
- 审查神经母细胞瘤中髓状细胞的双重作用 (支持和抗瘤).
- 为了检查骨髓状细胞在当前神经母细胞瘤治疗中的参与.
- 探索针对神经母细胞瘤中髓状细胞的新型治疗策略.
主要方法:
- 文学评论总结了神经母细胞瘤中髓状细胞的功能.
- 在现有治疗方案中对髓状细胞参与的分析.
- 探索针对髓状细胞的新兴策略.
主要成果:
- 与瘤相关的髓状细胞可以作为效应细胞发挥作用,特别是在抗GD2免疫疗法中.
- 准CD47/SIRPα等轴可以增强髓状细胞的参与.
- 削减或阻断髓状细胞透可能是有效的,但也可能去除有益的效应细胞.
结论:
- 重编程抑制性髓状细胞是一种潜在的最佳策略.
- 这种方法可以逆转免疫抑制特征,同时保持效应器功能.
- 重新激活瘤透T细胞是髓状细胞重编程的一个关键结果.
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