同步双重原发性恶性瘤及其可能的共同基因:一种罕见的临床实体
Na Hu1, Gang Yan2, Mao-Wen Tang1
1Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Current medical imaging
|December 13, 2023
概括
这项研究确定了同步结直肠癌 (CRC) 和脏清细胞癌 (ccRCC) 患者的共同基因,包括CA9,IBSP和FGG. 图像和生物信息分析增强了对这些双重原发性瘤的理解.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 生物信息学是一种生物信息学.
背景情况:
- 同步原发性恶性瘤,如结直肠癌 (CRC) 和清细胞癌 (ccRCC),存在诊断和治疗方面的挑战.
- 准确的成像和分子剖析对于了解同时发生的癌症的病原性至关重要.
研究的目的:
- 分析18F-FDG PET/CT和对比度增强CT的成像结果,用于同步CRC和ccRCC的患者.
- 通过生物信息分析识别CRC和ccRCC之间的共享基因.
主要方法:
- 一位患有同步CRC和ccRCC的患者的回顾性分析,该患者接受了18F-FDG PET/CT和对比度增强CT.
- 生物信息分析以确定CRC和ccRCC之间差异表达和共同表达的基因.
主要成果:
- 18F-FDG PET/CT显示CRC的高代谢活性,而CT显示非FDG狂热的质与ccRCC一致.
- 组织病理学证实了同步的双重原发性恶性瘤.
- 生物信息分析表明,同步CRC和ccRCC与碳酸酶9 (CA9) 的共同表达,整蛋白结合性蛋白 (IBSP) 和纤维素γ链 (FGG) 之间的相关性.
结论:
- 18F-FDG PET/CT和对比度增强CT是诊断同步CRC和ccRCC的宝贵工具.
- 本案例研究和生物信息学分析有助于了解同步结直肠和癌背后的分子机制.
更多相关视频
09:33Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
Published on: August 25, 2023
1.2K
09:49Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
9.6K
相关概念视频
02:21Cancers Originate from Somatic Mutations in a Single Cell
12.0K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.0K
01:20The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
01:33Cancer-Critical Genes I: Proto-oncogenes
8.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.9K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K