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Updated: Jul 8, 2025

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免疫受损宿主中的SARS-CoV-2:通过全基因组测序阐明康复性血疗法和病毒进化

Helena Seth-Smith1,2, Silvan Vesenbeckh3,4, Adrian Egli1,2

  • 1Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.

BMJ case reports
|December 13, 2023
PubMed
概括

长时间的SARS-CoV-2感染在免疫功能低下的患者中可能导致显著的病毒演变. 这一案例突出显示了突变率的升高,并为关注变异 (VoCs) 的发展提供了证据.

关键词:
在 COVID-19 疫情中,药物:传染病传染病.血液学 (包括输血)免疫学产品和疫苗.公共卫生 公共卫生

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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