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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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带选择性的全场光学连贯性断层扫描.

Haonan Zong, Celalettin Yurdakul, Jian Zhao

    Optics express
    |December 13, 2023
    PubMed
    概括

    这项研究介绍了键选择性全场光学一致性断层扫描 (BS-FF-OCT),这是一种用于无标签3D化学成像的新技术. BS-FF-OCT成功地可视化了各种样品,从聚合物珠到复杂的生物组织.

    科学领域:

    • 生物医学光学 生物医学光学
    • 频谱学是一种光谱学.
    • 3D成像是3D成像中的一种.

    背景情况:

    • 光学一致性断层扫描 (OCT) 为研究和临床使用提供无标签,非侵入性的3D成像.
    • 传统的OCT缺乏化学信息,限制了其诊断能力.
    • 开发新的OCT化学分析方法对于先进的生物和医学应用至关重要.

    研究的目的:

    • 开发和演示一种新的债券选择性全场OCT (BS-FF-OCT) 技术.
    • 在高度分散的样本中实现无标签的3D化学对比.
    • 扩大OCT的应用范围,超越结构成像.

    主要方法:

    • 使用脉冲中红外激光诱导OCT信号的光热调制.
    • 实施了一种债券选择性全场OCT (BS-FF-OCT) 系统.
    • 将该技术应用于各种样本,包括聚合物珠,手术口罩,细胞球体,C. elegans和老鼠大脑组织.

    主要成果:

    • 成功完成了1微米PMMA珠在阿加罗斯凝中的无标签,3D粘合选择性成像.
    • 从手术口罩中获得聚烯纤维的3D高光谱成像.
    • 在癌细胞球状体和C. elegans等生物样本上展示了BS-FF-OCT.

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  • 在小鼠大脑组织中可视化高度分散的髓质轴突,使用优化的脉冲计时配置.

    • 结论:

    • BS-FF-OCT 允许对散射样品进行无标签,粘接选择性的3D成像.
    • 该技术提供了有价值的化学信息,补充了 struktural OCT 数据.
    • 在生物研究和临床诊断中,BS-FF-OCT显示出各种应用的巨大潜力.