在健康的年轻成年人中循环蛋白质表达模式
Adrien Specht1, German Kolosov1, Katie L J Cederberg1
1Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California, USA.
Sleep health
|December 13, 2023
概括
数百种血蛋白显示人类的日常节律,揭示了对昼夜生物学和个性化医学的新见解. 这项研究确定了超过一千种节律蛋白,其中许多具有一致的日常模式.
科学领域:
- 时间生物学 时间生物学
- 蛋白质组学是指蛋白质组学.
- 人体生理学 人体生理学
背景情况:
- 循环节律调节了许多生理过程.
- 了解血蛋白的每日波动对于人类健康至关重要.
- 以前的研究已经暗示了蛋白质组的昼夜变化,但缺乏全面的分析.
研究的目的:
- 为了研究血蛋白质组的24小时波动.
- 为了确定表现出内源性昼夜节律的特定蛋白质.
- 探索对昼夜医学的影响.
主要方法:
- 在受控条件下,每小时从17名健康成年人采取血样本,并按照典型的睡眠和清醒时间表进行.
- 使用SomaScan平台对6916种蛋白质进行定量蛋白质组分析.
- 统计分析使用带有混合效应的共声波模型来检测节奏性.
主要成果:
- 1063种蛋白质 (15%) 显示出显著的每日节律性.
- 在这两种条件下,431种蛋白质 (6.2%) 显示出一致的内源性昼夜节律.
- 有相当数量的节律蛋白在下午晚些时候或早晨达到峰值.
结论:
- 数百种血蛋白在人类中表现出内生昼夜节律性.
- 这一发现为发现新的昼夜调节路径开辟了道路.
- 它支持将昼夜节律知识整合到个性化和预测医学中.
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