放射学与肝转移中治疗反应的相关性
Leila Mostafavi1, Fatemeh Homayounieh2, Felix Lades3
1Department of Radiology, Massachusetts General Hospital and the Harvard Medical School, Boston, Massachusetts, USA (L.M., F.H., V.M., G.J.H., M.K.K., S.R.D.); Tumor Imaging Metrics Core (TIMC), Dana-Farber/Harvard Cancer Center, Boston, Massachusetts, USA (L.M., G.J.H.).
肝转移的放射学分析显示了稳定疾病,部分反应和进展性疾病的不同模式. 然而,仅仅基线放射学无法预测乳腺癌患者的治疗反应.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 医学成像分析 医学成像分析
背景情况:
- 乳腺癌转移性肝病需要准确的反应评估.
- RECIST 1.1标准是评估治疗反应的标准.
- 放射学为疾病特征提供了定量成像功能.
研究的目的:
- 为了评估肝转移的放射学在稳定性疾病 (SD),部分响应 (PR) 和渐进性疾病 (PD) 中的差异,使用RECIST 1.1.
- 为了确定基线放射学是否可以预测治疗反应.
主要方法:
- 通过对比度增强的CT扫描对肝转移的半自动细分.
- 从基线和后续扫描中提取第一级和高级放射学特征.
- 后勤回归和随机森林分类器用于区分响应类别.
主要成果:
- 放射学显示了SD,PR和PD组之间的差异.
- 随机森林实现了差异化PR的AUC为0.845,PD的AUC为0.731.
- 在基线时,没有观察到放射性物质的显著差异来预测反应.
结论:
- 用半自动细分的放射学可以在肝转移中区分响应类别.
- 仅仅基线放射性数据不足以预测治疗反应.
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