艾滋病毒和骨折:风险,评估和干预措施
D M McGee1, A G Cotter1,2
1Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Republic of Ireland.
HIV medicine
|December 13, 2023
概括
携带艾滋病毒的人 (PLWH) 经历更多的骨折. 早期风险评估,重点关注可修改因素和骨密度,对于预防骨折至关重要.
科学领域:
- 骨健康和流行病学
- 艾滋病毒药物和并发症管理
背景情况:
- 骨折是艾滋病毒感染者 (PLWH) 的重要关注点.
- 在艾滋病毒护理中,管理并发症至关重要.
- 早期的骨完整性损失和临床骨折是PLWH中公认的问题.
研究的目的:
- 审查PLWH中骨折的流行病学.
- 总结一下导致骨折风险的因素.
- 描述PLWH的骨折风险评估和干预策略.
主要方法:
- 审查最近的元分析和流行病学数据.
- 分析导致骨折风险的因素,包括生活方式和抗逆转录病毒疗法.
- 评估骨折风险评估工具及其在PLWH中的准确性.
主要成果:
- PLWH的骨折率明显高于一般人群.
- 在男性和注射毒品使用者中观察到更高的风险.
- 可修改的危险因素包括BMI,药物使用,药物,虚弱和C型肝炎.
- 诺福维尔暴露与骨折风险有关;埃法维伦兹可能具有保护作用.
- 标准骨折风险工具低估了PLWH中的风险;包括HIV作为二次骨质疏松症的原因,骨矿物质密度提高了准确性.
结论:
- 及时评估风险因素,脆弱性和跌倒,以及骨密度成像,可以预防PLWH的骨折.
- 国际指导方针提供查和生活方式修改建议.
- 双酸盐在PLWH中安全有效预防骨折.
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