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与儿童行为相关的父亲和母亲预先怀孕和母亲怀孕的尿甲酸代谢物和BPA度

Jordana Leader¹, Lidia Mínguez-Alarcón², Paige L Williams³

¹Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Environment international

|December 13, 2023

概括

父母在受孕前接触某些化学物质可能会影响孩子的行为. 孕前怀孕和孕期甲酸代谢物 (MBzP) 暴露与外部化问题增加有关,而MCOP暴露与较少的行为问题有关.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
儿科健康儿科健康

背景情况:

关于父母预孕暴露对后代健康的影响的流行病学数据有限.
毒理学研究表明,环境化学物质的暴露可能会影响儿童的发育.
了解这些暴露对公共健康至关重要.

研究的目的:

调查母亲和父亲的预孕和母亲怀孕之间的关联,尿液中甲酸代谢物和双甲 (BPA) 度和儿童行为.
分析"孕前环境暴露和儿童健康影响研究" (PEACE) 的数据.
评估特定化学物质暴露与6至11岁儿童行为结果之间的关系.

主要方法:

前性队列研究分析包括134名母亲,87名父亲和157名儿童.
线性混合模型用于估计经共变量调整的关联.
与儿童行为评估系统-3 (BASC-3) T-分数相比,测量了尿甲酸代谢物和BPA度.

主要成果:

较高的孕产妇预孕或怀孕单乙酸盐 (MBzP) 与增加的儿童外部化问题有关.
较高的孕产妇预先怀孕单碳酸甲酸 (MCOP) 暗示与较低的外部化问题有关.
较高的父性偏见MCOP暗示与较低的内化问题和行为症状有关.

结论:

孕产妇预先怀孕和怀孕 MBzP 暴露与父母报告的儿童行为更差有关.
母亲和父亲的先入为主的MCOP度与较低的儿童行为评分有关.
研究结果强调了父母环境暴露对儿童行为的潜在影响.

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