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Updated: Sep 3, 2026

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
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在大鼠血中使用UHPLC-HESI-LTQ-MS开发和验证多克索鲁比辛和拉帕提尼布的生物分析方法

Shaik Khaja Moinuddin1, Pirangi Srikanth1, Parul Sharma1

  • 1Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab 160 062, India.

Journal of chromatographic science
|December 13, 2023
PubMed
概括

一种新的超高性能液态染色 - 加热电子喷雾电离 - 质谱法 (UHPLC-HESI-MS) 方法准确量化多克索鲁比 (DOX) 和拉帕提尼布 (LAP). 这种经过验证的方法对于在配方和生物样本中分析这些癌症药物至关重要.

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...