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生物仿真向纳米辅助剂用于针对整体生物膜相关感染的声动力学和时间多重免疫疗法

Lingtian Wang¹, Changqing Zhang¹, Jinhui Zhao²

¹Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai, Jiao Tong University School of Medicine, Shanghai, 200233, P. R. China.

Advanced materials (Deerfield Beach, Fla.)

|December 13, 2023

概括

这项研究引入了一种新的多种免疫疗法和声动疗法方法,用于治疗生物膜相关感染 (BRIs). 按时间顺序给药的纳米辅助剂针对不同的感染阶段,增强治疗疗效,促进组织修复.

科学领域:

生物医学工程生物医学工程
免疫治疗是一种免疫疗法.
纳米技术纳米技术

背景情况:

与生物膜相关的感染 (BIR) 由于耐药性和免疫逃避,造成了重大临床挑战.
目前的治疗方法往往无法解决BRI的动态,多阶段性质.

研究的目的:

开发一个时间顺序的多种免疫疗法和声动疗法治疗BRI的策略.
设计巨细胞膜装饰的纳米辅助剂,以便在不同感染阶段有针对性地输送治疗剂.

主要方法:

装饰着巨细胞膜的纳米辅助剂的制造,装载着细胞酸 - 氨酸 - 氨酸寡度氧核酸 (CPG-ODN) 或微型RNA (miR) -21-5p.
利用CPG-ODN用于早期和晚期的感染控制 (中性粒细胞外细胞陷,M1巨细胞极化) 和生物膜根除的声动疗法.
使用miR-21-5p用于修复阶段 (M2巨分极),以减少炎症并促进组织融合.

主要成果:

装有CPG-ODN的纳米辅助剂有效地捕获了微生物和极化巨细胞到M1表型,而声动疗则消除了生物膜.
装有miR-21-5p的纳米辅助剂成功诱导了M2巨细胞的两极分化,抑制了炎症并有助于组织修复.
时间顺序的治疗策略表明了跨多个阶段的BIR综合管理.

结论:

这种创新方法为BRI的时间处理提供了一个有希望的解决方案.
多阶段,多疗法策略有效消除感染,调节免疫反应,促进组织恢复.
开发的纳米辅助剂系统具有重要的临床应用潜力,用于管理复杂的生物膜感染.

关键词:

与生物膜相关的感染.按时间顺序进行多种免疫疗法.巨细胞的两极分化纳米助剂是一种纳米助剂.声动力学疗法声动力学疗法

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