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在慢性自发性疹中,抗FcεRI和抗IgE自身抗体的数量增加和功能亲和力/贪性下降
L Joerg1, N Mueller-Wirth2, K Kammermann2
1Division of Allergologie and Clinical Immunology, Department of Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
European annals of allergy and clinical immunology
|December 13, 2023
概括
自免疫性慢性自发性疹 (aiCSU) 涉及对IgE和FcεRI的自身抗体. 虽然抗体水平增加了,但他们的狂热性在六个月内下降了,这表明基基细胞激活测试更好地诊断aiCSU.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 过敏 过敏是一种过敏.
背景情况:
- 自身免疫性慢性自发性疹 (aiCSU) 的特征是针对高亲和性IgE受体 (FcεRI) 和IgE的自身抗体.
- 在aiCSU中,自身抗体存在与疾病活性之间的相关性是不一致的,这表明像贪这样的功能方面可能至关重要.
研究的目的:
- 这项研究旨在调查aiCSU患者在六个月内对IgE和FcεRI的自身抗体数量和激活度的变化.
- 在aiCSU中探索自身抗体激发,基细胞激活和疾病活性之间的关系.
主要方法:
- 从49名患有慢性自发性疹 (CSU) 的患者和30名健康对照组的血清样本在基线和六个月后收集.
- 与酶相关的免疫吸收试验 (ELISA) 用于量化对IgE和FcεRI的自身抗体,并评估它们的活性.
- 使用基激活测试 (CU-BAT) 测量基激活.
主要成果:
- 患有CSU的患者在六个月后显示出抗FcεRI和抗IgE自身抗体的数量显著增加.
- 与此同时,这些自身抗体的狂热性在同一时期显著下降.
- 没有观察到基细胞激活频率的显著变化,自身抗体激发与基细胞激活没有相关性.
结论:
- 在CSU患者中,抗FcεRI和抗IgE自身抗体的数量和强度随着时间的推移而波动.
- 基细胞激活试验 (CU-BAT) 似乎更适合用于诊断aiCSU,而不是测量自身抗体激活度.
- 自体抗体激发和基细胞激活之间缺乏相关性表明,其他因素有助于aiCSU的发病.
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