气体等离子体技术:从生物分子氧化回氧化研究到医疗治疗
1ZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
Biochemical Society transactions
|December 13, 2023
概括
医疗气体血疗法使用活性氧和物种 (RONS) 来治疗伤口. 了解RONS是优化各种疾病等离子体治疗的关键.
科学领域:
- 生物医学工程 生物医学工程
- 血物理学的等离子体物理学
- 皮肤病学 皮肤病学
背景情况:
- 物理等离子体是气体电离的结果,在环境空气中产生反应性氧和物种 (RONS).
- 2010年代的创新使得在体温下气体等离子体的临床应用成为可能,揭示了其抗菌性质.
- 医疗气体等离子器件在2013年获得了欧洲批准,用于伤口愈合,使成千上万的患者受益.
研究的目的:
- 探索气体等离子体介导的生物医学效应的机制基础.
- 了解各种RONS在血治疗中的复杂作用.
- 为突出针对特定治疗应用量身定制RONS的潜力.
主要方法:
- 审查用于医疗用途的气体等离子体生成技术进步.
- 分析医疗气体等离子体的抗微生物功效和临床试验结果.
- 研究由血产生的RONS的不同类型和度概况.
主要成果:
- 气体血疗法在临床上已获得批准,并广泛用于慢性伤口愈合.
- 气体等离子体的生物医学效应越来越多地归因于RONS.
- RONS的多样性和动态性质带来了挑战,但也为治疗定制提供了机会.
结论:
- 了解RONS的作用对于理解气体等离子体的治疗机制至关重要.
- RONS的复杂性需要进一步的研究,以获得完整的机械洞察力.
- 气体等离子体通过控制RONS生产,为氧化还原研究和量身定制的疾病治疗提供了多功能工具.
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