通过光学连贯性断层扫描测量的底部结构变化的模式 血管造影作为急性山病的潜在标志物
Yuancheng Zhao1, Huan Zou1, Wei Fan1
1Department of Ophthalmology, Second Affiliated Hospital of Army Medical University, Chongqing, China.
Translational vision science & technology
|December 13, 2023
概括
光学连贯断层扫描血管学揭示了视网膜血液流动和高海拔地区的厚度的变化. 视网膜神经纤维层厚度增加可能表明急性山病 (AMS) 的风险较低.
科学领域:
- 眼科医生 眼科 眼科
- 高度医学 高度医学
- 医疗成像医学成像
背景情况:
- 高海拔环境带来了生理上的挑战.
- 急性山病 (AMS) 是一个常见的高度疾病.
- 了解生理变化对于AMS的预防和管理至关重要.
研究的目的:
- 使用OCTA评估视网膜和胆道血液流动和结构的变化.
- 在健康的志愿者中确定与AMS相关的参数,这些志愿者上升到高海拔.
主要方法:
- 光学连贯断层扫描血管造影 (OCTA) 用于检查45名健康志愿者.
- 检查是在海平面进行的,在第一,第三和第五天是在高海拔地区进行的.
- 使用标准化问卷评估AMS症状,并将数据与OCTA参数相关联.
主要成果:
- 高海拔暴露导致视网膜表面血管扩大,深层收缩,视网膜层的血管密度和厚度增加.
- 状大血管密度下降,而视网膜神经纤维层 (RNFL) 厚度增加.
- 在特定的斑点区域增加RNFL厚度与较低的AMS得分相关.
结论:
- 高海拔低氧会导致视网膜血管结构和厚度发生显著变化.
- 视网膜神经纤维层 (RNFL) 厚度变化,特别是在近中心斑点中,可能作为AMS风险的生物标志物.
- 由OCTA衍生的视网膜结构变化可以帮助评估AMS风险.
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