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Updated: Jul 8, 2025

Diagonal Method to Measure Synergy Among Any Number of Drugs
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Published on: June 21, 2018

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医疗保险药品价格谈判:选择治疗替代方案的复杂性,以估计比较有效性

Inmaculada Hernandez1, Emma M Cousin2, Olivier J Wouters3

  • 1Skaggs School of Pharmacy, University of California San Diego.

Journal of managed care & specialty pharmacy
|December 13, 2023
PubMed
概括

医疗保险和医疗补助服务中心 (CMS) 将通过使用治疗替代品来谈判药品价格. 本研究提出了选择顶级医疗保险药物替代品的方法,解决了多种适用药物的复杂性.

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When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
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Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
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