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发现和机械研究的新 Mycobacterium结核病 ClpP1P2 抑制剂

Yang Yang1,2, Ninglin Zhao1, Xin Xu1

  • 1Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.

Journal of medicinal chemistry
|December 13, 2023
PubMed
概括

塞迪拉尼布抑制了mtbClpP1P2酶复合体,这对Mycobacterium结核病的生存至关重要. 这一发现为开发新的抗结核药物提供了一种新的策略,通过向这种必不可少的细菌蛋白.

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