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Updated: Jul 8, 2025

Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy
08:46

Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy

Published on: June 13, 2025

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细胞拉伸激活了一个ATM机械转导通路,该通路重塑细胞骨和染色质

Giulia Bastianello1, Giancarlo Porcella2, Galina V Beznoussenko2

  • 1IFOM, the FIRC Institute of Molecular Oncology, 20139 Milan, Italy; Oncology and Haemato-Oncology Department, University of Milan, 20122 Milan, Italy.

Cell reports
|December 13, 2023
PubMed
概括

ATAXIA-telangiectasia突变 (ATM) 激酶通过细胞骨架和活性氧物种 (ROS) 对机械应激做出反应,影响ATAXIA-telangiectasia (A-T) 中的细胞刚性和迁移. 这揭示了ATM超出DNA损伤之外的机械反应作用.

关键词:
机动机和ATR的ATM和ATR是什么CP: 细胞生物学 细胞生物学科普:分子生物学 分子生物学对DNA损伤的反应反应这就是ROSOS ROS.亚达克西亚 (ataxia) 是一个对电脉切割的过程.细胞伸展延伸 细胞伸展检查站的检查点在这种情况下,染色染色素细胞骨架 细胞骨架间歇性迁移是间歇性的迁移.机械应力 机械应力 机械应力

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