连接组织疾病相关的肺高血压:综合性综述
Vikramjit Khangoora1, Elana J Bernstein2, Christopher S King1
1Advanced Lung Disease and Transplant Program Inova Fairfax Hospital Falls Church Virginia USA.
Pulmonary circulation
|December 13, 2023
概括
连接组织疾病 (CTD) 可以导致肺高血压 (PH),特别是在全身性硬化症 (SSc) 中. 早期查和血液动力学评估对于管理CTD-PH至关重要,尽管结果仍然比特异性PAH差.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 类风湿病学 类风湿病学
背景情况:
- 连接组织疾病 (CTD) 与各种形式的肺高血压 (PH) 有关.
- 肺动脉高血压 (PAH) 在CTD的患病率范围,在全身性硬化症 (SSc) 中最高,为8-12%.
研究的目的:
- 审查CTD和PH之间的关联.
- 为突出查,诊断和管理策略的CTD相关PH.
- 讨论CTD-PAH与异常性PAH相比的较差结果.
主要方法:
- 审查当前的文献和指导方针.
- 强调右心脏导管治疗用于血液动力学分析.
- 基于肺血管病变现型的治疗策略的讨论.
主要成果:
- 建议在SSc和相关CTD中进行PAH的常规查.
- 准确的诊断需要彻底的评估,包括右心脏导管.
- CTD-PAH的结果低于异常性PAH,特别是在SSc-PAH中.
结论:
- 对CTD-PAH的管理通常遵循异常性PAH指南.
- 肺外表现和并发症有助于更糟糕的结果.
- 建议提前转移肺移植并进一步研究病原体.
相关概念视频
01:30Pulmonary Hypertension: Classification and Pathogenesis
188
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
188
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.8K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.8K
01:20COPD: Pathogenesis and Clinical Features
288
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
288
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K