在丹麦胆汁酸性腹的流行病学
Martin L Kårhus1, Anne-Marie Ellegaard1, Matilde Winther-Jensen2
1Center for Clinical Metabolic Research, Copenhagen University Hospital - Herlev and Gentofte, Hellerup, Denmark.
Clinical epidemiology
|December 13, 2023
概括
胆酸腹 (BAD) 影响1-2%的人口,引起显著的症状. 这项研究发现,与普通人群相比,被诊断出来的个体往往健康状况和社会经济地位较差.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 胆汁酸性腹 (BAD) 是一种衰弱的疾病,其特点是经常排便,急迫性和便失禁.
- 它是结肠中胆汁酸过量的结果,通常用胆汁酸分离剂来管理.
- 尽管有SeHCAT测试的可用性,但诊断往往会延迟,导致一般人群的诊断不足.
研究的目的:
- 描述在丹麦被诊断患有胆酸性腹 (BAD) 的人口特征.
- 通过使用全国性的注册表来调查BAD的流行率和诊断趋势.
- 将BAD患者的健康状况和社会经济状况与普通人群进行比较.
主要方法:
- 从2003年到2021年,利用全国性的丹麦登记册来识别患有BAD的人.
- 通过SeHCAT测试转诊,然后在365天内处方胆酸分离剂来定义BAD群体.
- 对比BAD患者的人口,健康和社会经济参数与年龄和性别匹配的对照.
主要成果:
- 确定了5264名BAD个体,在丹麦各地存在显著的区域差异.
- 在研究期间,观察到SeHCAT测试,胆酸分离剂处方和BAD诊断的增加.
- 与对照组相比,BAD患者的并发症率更高,医疗保健利用率增加,教育程度和收入较低.
结论:
- 该研究成功地使用注册数据在丹麦确定了一大批患有胆酸性腹的人口.
- 被诊断为BAD的个人似乎有较差的健康结果和社会经济地位比一般的丹麦人口.
- 调查结果强调了与BAD相关的医疗保健准入和社会经济因素的潜在差异.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
335
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
335
01:17Chronic Bowel Disorders: Introduction
456
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
456
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
188
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
188
01:30Inflammatory Bowel Disease II: Crohn's Disease
253
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
253
01:17Drugs for Treatment of Diarrhea-Predominant IBS
179
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
179
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
124
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
124