在2型糖尿病患者中,肥胖模式,代谢异常和糖尿病病
Kun Zhang1, Wen Zhang1, Fangzhen Xia1
1Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China.
肥胖,无论是一般的还是腹部的,在2型糖尿病患者中显著增加糖尿病病 (DKD) 的风险. 代谢异常进一步放大了这种风险,突出了肥胖和代谢健康对DKD患病率的综合影响.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
背景情况:
- 肥胖是慢性病的一个已知的危险因素.
- 不同肥胖模式和代谢健康对糖尿病病 (DKD) 的具体影响需要进一步澄清.
研究的目的:
- 调查一般肥胖 (体重指数,BMI),腹部肥胖 (腰比,WHR) 和代谢异常与糖尿病病 (DKD) 的患病率之间的关联.
主要方法:
- 一项涉及中国上海4079名2型糖尿病患者的横截面研究.
- 根据BMI和WHR评估的肥胖;根据成人治疗小组III标准评估的代谢异常.
- 根据估计的膜过率或白蛋白与肌素的比率定义的DKD;使用Poisson回归与治疗权重的逆概率分析.
主要成果:
- 较高的BMI和WHR都独立地与增加的DKD患病率有关.
- 综合的一般和腹部肥胖症显示了最高的DKD几率 (PR 1.51).
- 肥胖对DKD的影响在具有更多代谢异常的患者中更为明显,显示出附加效应.
结论:
- 根据BMI和WHR评估的肥胖与DKD患病率有积极联系.
- 肥胖和新陈代谢异常对发展DKD的可能性产生增加的影响.
- 需要进一步的纵向研究,以了解肥胖和代谢状态在DKD发展中的因果关系.
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