成年人的细分膜性淋巴细胞病变
Shuangshuang Zhu1,2, Xiaoting Liu2, Shuling Yue2
1Department of Laboratory Medicine, Southern Medical University, Nanfang Hospital, Guangzhou, China.
Kidney diseases (Basel, Switzerland)
|December 13, 2023
概括
细分膜性结膜病变 (SMGN) 很少见,主要影响女性. 神经表皮生长因子类1蛋白 (NELL1) 被确定为成人SMGN病例中的主要向抗原.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病理学 病理学 病理学
- 免疫学 免疫学 免疫学
背景情况:
- 细分膜性结膜病变 (SMGN) 是一种罕见的病,临床病理特征鲜明.
- 了解SMGN的患病率和特征对于诊断和管理至关重要.
研究的目的:
- 在成年患者中调查细分膜性结膜病变 (SMGN) 的患病率和临床病理学特征.
- 在SMGN.中识别潜在的标抗原.
主要方法:
- 从2017年1月到2020年9月,对活检证明的SMGN成年患者的回顾性分析.
- 评估IgG子类,PLA2R,THSD7A和NELL1.1的淋巴细胞沉积.
- 对NELL1-阳性和NELL1-阴性SMGN之间的临床和病理特征的比较.
主要成果:
- 成人膜性病 (MN) 病例中,SMGN占0.51%.
- 孤立的SMGN主要影响女性 (74%),平均年龄为41.5岁;33.1%呈现出全性综合征.
- 在所有测试病例中,PLA2R和THSD7A染色结果是负的,而NELL1在43.0%的孤立SMGN病例中呈阳性.
- 与NELL1阴性病例相比,NELL1阳性SMGN的全综合征患病率较低.
结论:
- 细分膜性结膜病变 (SMGN) 是一种罕见的实体,主要影响成年女性.
- 神经表皮生长因子类1蛋白 (NELL1) 被确定为成人SMGN的主要向抗原.
- 大多数SMGN病例呈现出早期的膜性变化 (I或II阶段).
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