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病原体减少对康复期血总IgG和IgG子类概况的影响

Tomasz Wasiluk¹, Magdalena Sredzinska¹, Anna Rogowska¹

¹Regional Centre for Transfusion Medicine, Bialystok, Poland.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

|December 13, 2023

概括

病原体减少技术 (PRT) 在康复期血 (CP) 中不会显著改变IgG子类. 然而,随着利博弗拉 (RB) 治疗,观察到IgG4损失增加的轻微趋势,这需要进一步调查未来的流行病准备.

科学领域:

免疫学免疫学免疫学
输血医学输血医学
病毒学病毒学

背景情况:

康复性血 (CP) 是对新出现的病原体的关键早期治疗.
免疫球蛋白G (IgG) 子类在CP的中和活性中发挥作用.
病原体减少 (PR) 技术可以减轻与CP相关的病毒传播风险.

研究的目的:

评估三种商业PR技术对COVID-19康复性血 (CCP) 中的IgG和IgG亚类的影响.
为了比较amotosalen (AS) /UVA, riboflavin (RB) /UVB和甲基蓝 (MB) 处理对IgG数量和分布的疗效.
评估PR技术的适用性,以确保未来流行病中CP的安全性和有效性.

主要方法:

36个非性CPC捐款被分为三个组进行并排比较.
评估了AS/UVA,RB/UVB和MB治疗对总IgG和IgG子类的影响.
对IgG子类的量化和分布分析是使用nephelometric分析仪进行的.

主要成果:

在所有三种PR技术中都没有观察到IgG子类分布的显著变化.
在AS,RB和MB治疗之间,IgG1和IgG2度的中位损失没有显著差异.
不显著的趋势表明,与AS和MB治疗相比,在RB治疗后IgG4的中位数损失较高.

结论:

商业上可用的PR系统 (AS,RB,MB) 在CCP中没有显著改变IgG亚类的分布.
随着RB治疗而增加IgG4损失的潜在趋势需要进一步调查.
在CP中保持IgG完整性,PR技术似乎是可行的,小的子类变异需要继续研究.

关键词:

在COVID-19康复期的血中.康复期间的血.的IgG子类的IgG子类.中和抗体的抗体.减少病原体的减少

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