阿佩林-13对代谢疾病和运动的有益作用
Ruiming Wen1, Ruiqi Huang2, Ke Xu1
1School of Sports Health, Shenyang Sport University, Shenyang, Liaoning, China.
Frontiers in endocrinology
|December 13, 2023
概括
阿佩林-13是一种阿迪波金,通过调节氧化应激,炎症和能量代谢来影响代谢疾病. 运动可以调节阿佩林-13,为代谢障碍提供潜在的治疗益处.
科学领域:
- 内分泌学 在内分泌学.
- 代谢研究研究 代谢研究
- 运动生理学 运动生理学
背景情况:
- 阿佩林是一种G蛋白结合受体APJ连接体,具有多个亚型,包括活性阿佩林-13.
- 阿佩林-13作为参与调节氧化应激,炎症,亡和能量代谢的阿迪波金作用.
- 关于阿佩林-13在代谢状态中的作用的现有研究提出了相互矛盾的发现.
研究的目的:
- 审查阿佩林-13与代谢疾病之间的关系.
- 探索运动对阿佩林-13水平的影响及其影响.
- 建立基于阿佩林-13的代谢疾病治疗策略的理论基础.
主要方法:
- 对Apelin-13,代谢疾病和运动研究的文献综述.
- 对Apelin-13的生物功能进行当前研究的分析.
- 关于运动对阿佩林-13的影响的综合证据.
主要成果:
- 阿佩林-13在各种与代谢健康相关的生物过程中发挥作用.
- 关于阿佩林-13与不同代谢状况的确切关联存在争议.
- 阿佩林-13被确定为一种运动敏感因子,有可能减轻代谢疾病.
结论:
- 阿佩林-13是代谢调节和疾病的重要因素.
- 运动影响阿佩林-13,表明其作为运动敏感治疗点的潜力.
- 需要进一步的研究来澄清Apelin-13的作用,并优化其在治疗代谢疾病中的使用.
相关概念视频
01:20Exercise and Cardiovascular Response
825
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
825
01:25cAMP-dependent Protein Kinase Pathways
6.4K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
6.4K