在人工流产期间,合布托福尔与布托尔醇的有效剂量中位数:一项随机对照试验
Yuling Zheng1, Jinping Huang2, Ying Mai1
1Department of Anesthesiology, The Affiliated Shunde Hospital of Jinan University, Foshan, China.
Frontiers in medicine
|December 13, 2023
概括
添加布托芬醇到人工流产的propofol麻醉剂显著降低了所需的propofol剂量,并减少了注射部位和子宫疼痛. 这种组合在手术过程中提高了患者的舒适性和安全性.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在无痛堕胎中,醇-阿片类药物组合是常见的.
- 布托芬醇可能会降低普罗波福尔剂量和不良事件.
研究的目的:
- 为了确定布托芬醇是否降低了普罗波福的中位有效剂量 (ED50).
- 评估布托芬醇对普罗波福尔注射疼痛和术后子宫疼痛的影响.
主要方法:
- 一项随机,双盲,受控的研究,涉及54名接受无痛人工流产的女性患者.
- 患者被分配单独接受普罗波 (P组) 或普罗波与10μg/kg的布托尔法醇 (PB组).
- 使用探针回归分析Propofol ED50;记录了总剂量,恢复时间和不良事件.
主要成果:
- 普罗波的ED50在布托芬醇组 (1.555毫克/公斤) 与仅提供普罗波的组 (2.477毫克/公斤) 相比显著较低.
- 布托芬醇组 (110.4毫克与150.7毫克相比) 的总普罗波福尔消费量减少.
- 注射部位疼痛的发生率 (20.7%对比76%) 和子宫疼痛 (6.9%对比72%) 显著低于butorphanol.
结论:
- 将普罗波与10μg/kg的布托尔醇结合起来,有效地降低了无痛人工流产的普罗波ED50.
- 这种组合显著降低了注射部位疼痛和术后子宫收缩疼痛的发生率.
- 丁醇的同时使用可提高无痛人工流产过程中的安全性和舒适性.
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