长效注射性暴露前预防的承诺和潜在的陷
Carey Pike1, Elzette Rousseau1, Linda-Gail Bekker1
1Desmond Tutu HIV Centre, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Southern African journal of HIV medicine
|December 13, 2023
概括
像注射式卡博特格拉维尔 (CAB LA) 这样的新的艾滋病毒预防选择比口服暴露前预防 (PrEP) 提供了更好的坚持. 了解实施挑战是最大限度地提高它们在南非的影响的关键.
科学领域:
- 公共卫生 公共卫生
- 预防传染病 预防传染病
- 药理学 药理学是指药理学的学科.
背景情况:
- 艾滋病毒暴露前预防 (PrEP) 的风景正在不断发展,目前有多种产品选择或正在开发中.
- 口服PrEP在南非面临着挑战,包括遵守问题和服务提供规模不足,限制其对艾滋病毒发病率的影响.
- 现有的和新兴的PrEP产品包括基于Tenofovir的口服PrEP,基于Dapivirine的阴道环,以及长效注射Cabotegravir (CAB LA).
研究的目的:
- 审查南非不断扩大的PrEP产品范围.
- 突出长效注射卡博特格拉维尔 (CAB LA) 的预期影响和实施考虑.
- 为了解决CAB LA和更广泛的PrEP选择背景的剩余临床和实施问题.
主要方法:
- 在南非审查当前和管道中的PrEP产品.
- 对口服PrEP,阴道环和CAB LA的临床疗效和安全数据的讨论.
- 对实施挑战的分析,包括遵守,服务交付和产品包装.
主要成果:
- 在南非批准了三种PrEP产品:基于Tenofovir的口服,Dapivirine阴道环和注射Cabotegravir.
- 长效注射卡博特格拉维尔 (CAB LA) 每隔2个月注射一次,具有很高的疗效,预计将于2023年底使用.
- 坚持挑战限制了口服PrEP在南非的影响.
结论:
- 注射式卡博特格拉维尔 (CAB LA) 准备对南非的艾滋病毒预防产生重大影响.
- CAB LA的关键实施问题包括了解突破性感染和优化PrEP选择框架内的服务提供.
- 需要制定战略,确保公平有效地获得各种PrEP选择,避免护理的再医疗化.
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