肠道微生物,互白素家族和高血压之间的关系:一个调解的门德尔随机化研究
Shiyao Zhao1, Jing Zhang1, Fuxia Ding1
1Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Frontiers in nutrition
|December 13, 2023
概括
这项研究确立了肠道细菌和高血压之间的遗传联系. 介素-1受体2型 (IL-1R2) 调解了Clostridium innocuum组对血压的影响,提供了新的干预点.
科学领域:
- 微生物组研究 微生物组研究
- 心血管遗传学 心血管遗传学
- 系统生物学 系统生物学
背景情况:
- 肠道微生物群影响血压,但与高血压的因果关系尚不清楚.
- 观察性研究面临着混因素和反向因果关系的挑战.
- 阐明肠道菌群与高血压之间的关系对于临床干预至关重要.
研究的目的:
- 为了确定特定肠道细菌和高血压之间的因果关系.
- 为了确定肠道菌群-高血压通路中的中间介质.
- 为了研究介质蛋白家族在高血压中的作用.
主要方法:
- 两个样本的门德尔随机化 (MR) 和中介MR分析.
- 分析了211种肠道细菌物种,结果是高血压.
- 逆方差加权估计和灵敏度分析.
主要成果:
- 两种细菌物种与高血压风险有积极关联;五种细菌物种与高血压风险有负面关联.
- 鉴定出一种介导体的,是2型互乐金-1受体 (IL-1R2).
- 克洛斯特无害菌群通过IL-1R2 (14.07%调解) 影响高血压.
结论:
- 证实了肠道微生物和高血压之间的遗传因果关系.
- 突出IL-1R2作为肠道高血压轴的关键调解器.
- 为新的临床高血压管理策略提供了见解.
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