妇女胸腔腹腔大动脉动脉瘤:关于她们的不良结果,仍然有许多问题
Ottavia Borghese1, Tara M Mastracci1,2
1Department of Cardiothoracic Surgery, St. Bartholomew's Hospital, London, UK.
Annals of cardiothoracic surgery
|December 13, 2023
概括
胸腔腹腔大动脉动脉瘤 (TAAA) 不成比例地影响女性,导致更糟糕的结果. 了解基于性别的差异对于改善女性患者的诊断和治疗策略至关重要.
科学领域:
- 血管外科 血管外科
- 大动脉疾病研究研究
- 基于性别的医学
背景情况:
- 胸腔腹腔大动脉动脉瘤 (TAAA) 每年影响约5.9 / 100,000人,男性占主导地位.
- 由于女性在临床试验中的代表性不足,TAAA流行病学和表现的性别相关变化数据有限.
- 荷尔蒙影响,解剖学差异和并发症有助于在女性中明显的TAAA进展和治疗考虑.
研究的目的:
- 为了突出 Thoracoabdominal Aortic动脉瘤 (TAAA) 缺乏研究的与性别相关的差异.
- 探索这些差异如何影响TAAA诊断,临床表现和患者结果.
- 倡导在TAAA护理中考虑性别特异因素的量身定制的管理策略.
主要方法:
- 对TAAA流行病学,临床表现和结果的性别相关变异现有文献的审查.
- 分析导致性别差异的因素,包括荷尔蒙影响,解剖学变异和并发症.
- 检查当前的TAAA管理策略,并将其与性别特异性考虑保持一致.
主要成果:
- 女性对TAAA的体验不同,较小的解剖结构可能在诊断时表明更先进的疾病.
- 女性性别是一个独立的风险因素,增加了主要的术后并发症,更长的住院时间,在内血管和开放TAAA修复后的死亡率更高.
- 目前的TAAA管理策略没有充分考虑与性别相关的差异,往往导致妇女的治疗延迟或出现.
结论:
- 在TAAA表现,并发症和结果方面存在显著的基于性别的差异.
- 目前的TAAA管理方法需要调整,以纳入性别特定的标准,以便及时和适当地治疗女性患者.
- 进一步的研究对于阐明和解决与性别有关的差异对于改善TAAA患者护理至关重要.
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