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Mohammed Ridha Moamin¹, Richard Allen¹, Steven Leslie Woods¹

¹Division of Clinical Medicine, School of Medicine & Population Health, Faculty of Health, Sheffield, United Kingdom.

Frontiers in immunology

|December 13, 2023

概括

经过新辅助化疗 (NAC) 后仍然没有疾病的高风险三阴性乳腺癌 (TNBC) 患者表现出周围血管 (PV) 免疫细胞的增加,特别是TIM-3+CD163+TAMs. 这表明了复发风险和潜在的免疫疗法标的新标记.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

三阴性乳腺癌 (TNBC) 是具有侵略性的,通常用新辅助化疗 (NAC) +/-免疫疗法治疗.
免疫细胞异质性,特别是巨细胞和T细胞,在TNBC中被注意到.
瘤中的周周血管 (PV) 免疫细胞可能会影响转移和抗瘤免疫力,但它们在人类中NAC过程中的作用尚不清楚.

研究的目的:

在NAC期间调查人类TNBC免疫格局的变化.
为了将免疫细胞的变化与患者的结果 (转移与无疾病) 相关联.
探索对接受NAC.的TNBC患者免疫疗法的疗效的影响.

主要方法:

多重免疫光和基于AI的图像分析被用来比较未经治疗和NAC治疗的TNBC中的免疫细胞.
量化了巨细胞,CD4+,CD8+T细胞和Tregs的表型,分布和细胞间接触.
在复发的患者和在NAC后保持无疾病 (DF) 的患者的瘤中比较免疫特征.

主要成果:

在NAC后,没有疾病的患者表现出增加的 stromal CD163+ TAMs,特别是表达TIM-3+的患者.
CD4+ T细胞始终在PV区域;TAMs和Tregs在NAC后的PV区域局部化.
观察到CD4+/CD8+ T细胞与CD163+ TAMs和Tregs的PV集群,并在NAC后持续存在.

结论:

在NAC之后的瘤残留中的Stromal TIM-3+CD163+TAMs可以预测TNBC的复发风险.
光伏免疫细胞聚类可能调节T细胞功能,并影响接受NAC的TNBC患者的免疫疗法的有效性.

关键词:

在TIM-3中,TIM-3是TIM-3.生物成像和生物检测诊断诊断诊断诊断诊断巨细胞是什么?巨细胞是什么?多重光学生物测试,编码多重光学生物测试.新辅助化疗 (NAC) 的使用三重阴性乳腺癌 (TNBC) 是一种

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