COVID-19和训练有素的免疫力:长期Covid的炎症负担
Jienan Gu1, Qianhui Liu2, Jiale Zhang1
1Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in immunology
|December 13, 2023
概括
严重的COVID-19会导致免疫细胞的长期表观遗传变化,可能会导致慢性炎症和相关疾病,通过一种称为训练免疫的过程.
科学领域:
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 传染性疾病 传染性疾病
背景情况:
- 严重的COVID-19会引发由天生的免疫细胞,特别是单细胞驱动的过度炎症.
- 表观遗传变化,包括单细胞中染色质可访问性增加,在恢复后持续存在.
- 这些变化表明血造干细胞和前代细胞 (HSPCs) 的重新编程,表明受过训练的免疫力.
研究的目的:
- 调查严重COVID-19后HSPC和单细胞的表观遗传重编程.
- 了解IL-6和IL-1β等细胞因子在调解这些表观遗传变化的作用.
- 探索持续的单细胞炎症对长期健康结果和疾病恶化的影响.
主要方法:
- 从重症COVID-19中康复的患者的单细胞和HSPC中表观遗传修饰的分析.
- 炎症媒介的量化,包括IL-6和IL-1β.
- 评估关键免疫相关基因的染色质可访问性.
主要成果:
- 在COVID-19恢复期间,单细胞发生了广泛的表观遗传变化的证据,与细胞因子生产和白细胞激活有关.
- 鉴定IL-6作为在单细胞中建立持久表观遗传修饰的关键媒介.
- HSPC重编程似乎是持续单细胞表观遗传记忆的起源.
结论:
- 单细胞中的COVID-19诱导的训练免疫可能会导致慢性炎症,组织损伤和急性后续症.
- 由于COVID-19引起的造血表观遗传重编程可能会加剧炎症性疾病.
- 需要进一步的研究来阐明机制,并开发针对IL-6的干预措施,以减轻持续的炎症.
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