在固体瘤中推进基于CAR的免疫疗法:CAR-巨细胞和中性粒细胞
Yanling Liang1,2, Qumiao Xu3,4, Qianqian Gao1
1Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, China.
Frontiers in immunology
|December 13, 2023
概括
化学抗原受体 (CAR) 工程化的巨细胞 (CAR-Ms) 和中性粒细胞 (CAR-Ns) 通过利用先天免疫细胞在癌症免疫疗法中显示出前景. 本综述探讨了它们的发展和治疗固体瘤的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 巨细胞和中性粒细胞是瘤微环境 (TME) 中关键的先天性免疫细胞.
- 这些细胞影响瘤进展 (血管新生,转移),但可以被设计为抗瘤效应.
- 它们对癌症免疫疗法应用具有重大潜力.
研究的目的:
- 审查巨细胞和中性粒细胞在采用细胞疗法中的应用.
- 专注于化学抗原受体 (CAR) 工程化的巨细胞 (CAR-Ms) 和中性粒细胞 (CAR-Ns).
- 总结CAR-Ms和CAR-Ns的构建策略,临床前和临床研究.
主要方法:
- 审查关于CAR-Ms和CAR-Ns的现有文献.
- 关于CAR工程策略的总结.
- 对CAR-Ms和CAR-Ns的临床前和临床数据的分析.
主要成果:
- 巨细胞和中性粒细胞可以被修改为癌症免疫治疗.
- CAR-Ms和CAR-Ns代表了采用细胞治疗的一个有前途的领域.
- 施工策略和研究表明它们在临床前和临床环境中的潜力.
结论:
- CAR-Ms和CAR-Ns为癌症免疫治疗提供了一种新的方法.
- 需要进一步的研究来解决局限性和挑战.
- 未来的方向旨在扩大其在治疗固体瘤中的应用.
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