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视网膜血管病理和脑缩在复发性复发性多发性硬化症中的关联
Eva Feodora Romahn1, Tun Wiltgen1, Matthias Bussas1
1Department of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Frontiers in immunology
|December 13, 2023
概括
光学连贯断层扫描血管造影显示,多发性硬化症 (MS) 患者的视网膜血管损失与大脑缩和残疾有关. 这种非侵入性成像可能有助于监测MS中神经退行.
科学领域:
- 眼科和神经科学 眼科和神经科学
- 医学成像和诊断 医学成像和诊断
背景情况:
- 多发性硬化症 (MS) 与视网膜血管稀薄和损失有关.
- 视网膜血管变化可能表明一种炎症性疾病表型和MS的更差预后.
- 与MS相关的视网膜血管变化,大脑缩和残疾之间的联系需要调查.
研究的目的:
- 调查视网膜血管结构变化与多发性硬化患者的大脑缩和残疾之间的关联.
- 为了确定视网膜光连贯断层扫描血管造影 (OCTA) 是否可以作为监测MS中神经退行症的工具.
主要方法:
- 研究了79名复发性复发性多发性硬化症患者的纵向观察队列.
- 年度评估包括扩展残疾状态量表 (EDSS),定时25英尺步行,符号数字模式测试 (SDMT),视网膜OCT,OCTA和脑MRI.
- 在至少20个月的时间内,分析了视网膜变化,大脑缩和残疾之间的个体内关联,不包括有视神经炎史的眼睛.
主要成果:
- 长度视网膜轴突和质细胞损失与灰质缩,皮质缩和膜体积损失相关.
- 表面血管复合体 (SVC) 血管损失与灰质和白质缩有关,独立于视网膜质细胞损失.
- 恶化的EDSS和SDMT得分与SVC和深血管综合体的显著稀缺有关.
结论:
- 视神经炎独立于视网膜血管系统的狭窄可能与MS中大脑缩和残疾相关.
- 视网膜OCTA显示出作为监测MS患者神经退行症的新工具的潜力.
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