在重复接种SARS-CoV-2 BNT162b2 mRNA疫苗后,与适应性免疫相关的快速过渡和持久的先天细胞因子变化
Margherita Rosati1, Evangelos Terpos2, Philip Homan3
1Human Retrovirus Pathogenesis Section, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, United States.
Frontiers in immunology
|December 13, 2023
概括
重复的BNT162b2 mRNA疫苗接种通过诱导快速和持续的细胞因子变化来提高免疫力. 这些变化与抗体反应相关,这表明在未感染的个体中有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 细胞因子和化学因子对于免疫对感染和疫苗接种的反应至关重要.
- 之前的研究确定了免疫参数,预测了对BNT162b2 mRNA疫苗的有益反应.
研究的目的:
- 检查COVID-19感染先前的志愿者第三次BNT162b2 mRNA接种疫苗后血清细胞因子和化学因子反应的动态.
主要方法:
- 在第三剂BNT162b2 mRNA疫苗注射后,使用化学发光试验和ELISA测量血清中细胞因子和化学因子水平.
- 使用ELISA和伪型检测分别量化了抗斯派克结合和中和抗体.
主要成果:
- 第三次接种疫苗维持了之前观察到的过渡性IL-15,IFN-γ,CXCL10/IP-10,TNF-α和IL-6反应.
- 炎症/抗炎性细胞因子签名在接种疫苗后持续长达一个月,这表明先天性免疫变化持续时间较长.
- 第三剂后CXCL13的短暂增加表明,生殖中心活性增强和抗Spike抗体反应更高.
- 改变IL-15特征和炎症/抗炎细胞因子概况与中和抗体水平相关.
结论:
- 重复的BNT162b2 mRNA疫苗接种诱导了快速,短暂和持久的系统性细胞因子变化.
- 这些细胞因子动态与先天性和适应性免疫反应有关,可以作为疫苗疗效的生物标志物.
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