在COVID-19患者中,SARS-Cov-2周期值和嗅觉功能障碍
Ali Goljanian Tabrizi1, Maliheh Mohseni Ashjerdi1, Matin Ghazizadeh1
1Department of Otolaryngology, Head and Neck Surgery, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.
Iranian journal of otorhinolaryngology
|December 13, 2023
概括
较高的病毒载荷,以较低的初始周期值 (Ct) 值表示,与COVID-19患者更严重的嗅觉功能障碍 (OD) 有关. 较低的Ct值也预测感染后气味恢复的持续时间更长.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 嗅觉功能障碍 (OD) 是COVID-19的一个常见症状,但其与病毒载荷的关系尚不清楚.
- 之前的研究已经产生了不一致的结果,关于嗅觉功能障碍严重程度/持续时间和COVID-19患者的病毒载荷之间的关联.
研究的目的:
- 研究COVID-19患者初始病毒载量 (Ct值) 与嗅觉功能障碍的严重程度和恢复时间之间的关联.
主要方法:
- 对309名COVID-19患者进行前性队列研究.
- 在症状出现的两个月内,使用宾夕法尼亚大学气味识别测试 (UPSIT) 评估初始鼻循环值 (Ct) 和嗅觉功能.
主要成果:
- 在28.8%的患者中诊断出无嗅 (完全失去嗅觉),严重的COVID-19和住院治疗的比率更高.
- 较低的初始Ct值与增加的OD严重程度和更长的恢复时间有显著的相关性.
- 恢复了嗅觉的患者的Ct值显著降低,与那些仍然患有OD的患者相比.
结论:
- 最初的病毒载量 (Ct值) 是COVID-19中嗅觉功能障碍严重程度和恢复时间的重要预测指标.
- 这些发现可能有助于理解COVID-19相关的嗅觉功能障碍背后的机制.
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