达普森诱导的粒状胆固醇性肝炎被类固醇缩小剂揭露:一个病例报告
Shahana Prakash1,2, Matthew Gosse3, Tomohiro Tanaka2,4
1Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Case reports in gastroenterology
|December 13, 2023
概括
达普森可以引起药物诱导性肝损伤 (DILI) 和罕见的肝脏颗粒瘤. 这一案例突出显示,DILI在接受治疗的患者中逐渐减少类固醇后呈颗粒瘤.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 达普森是已知的药物诱导性肝损伤 (DILI) 的原因之一.
- 肝脏颗粒瘤形成是DILI的一个罕见表现.
- 达普松,类固醇和肝损伤之间的相互作用尚未完全理解.
研究的目的:
- 描述一种罕见的达普诱导的肝脏颗粒瘤病例.
- 为了突出DILI在类固醇逐渐减少后表现出来的潜力.
- 强调在无法解释的肝损伤的情况下考虑达普松的重要性.
主要方法:
- 一个67岁的女性患有黄的病例报告.
- 肝脏活检显示了非死性肝脏颗粒瘤.
- 排除肝损伤的传染病和自身免疫病因.
主要成果:
- 患者出现了黄和肝酶升高后,同时启动达普松和普雷尼松治疗皮肤炎.
- 肝脏活检显示肝脏颗粒瘤,归因于达普森诱导的肝损伤.
- 在停用达普松后,肝功能正常化,支持诊断.
结论:
- 达普森诱导的肝损伤可能会出现肝脏颗粒瘤,这是一个罕见的发现.
- 当药物联合启动时,在类固醇逐渐减少后,DILI可能会变得明显.
- 在药物诱导的肝损伤的差异诊断中,应考虑达普森,特别是当有颗粒瘤时.
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