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电子烟蒸汽破坏了人类肺上皮细胞的关键代谢途径

Mohammed A Assiri¹, Sahar R Al Jumayi¹, Shuruq Alsuhaymi²

¹Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

|December 13, 2023

概括

电子烟 (EC) 导致肺细胞死亡和氧化应激. 我们的研究表明,ECs破坏了必不可少的细胞代谢,包括氨基酸和脂肪酸通路,突出显示了复杂的毒性.

科学领域:

毒理学毒理学毒理学
代谢学代谢学代谢学
细胞生物学细胞生物学

背景情况:

电子烟 (EC) 的使用正在增加,这与通过氧化应激和炎症引起的肺毒性有关.
细胞代谢对于恒温稳定至关重要,但EC对细胞代谢的影响在很大程度上是未知的.

研究的目的:

在人类肺上皮细胞中研究ECs诱导的代谢变化 (A549).
评估EC对细胞活力,氧化应激和细胞代谢的影响.

主要方法:

在暴露于不同EC蒸汽提取物度的A549细胞上使用非向的代谢学方法.
评估了细胞活力,氧化应激标志物和全球代谢概况.

主要成果:

ECs诱导了度依赖的细胞死亡和增加了氧化应激.
代谢分析揭示了关键途径的独特代谢干扰,包括氨基酸,脂肪酸,谷,和酸盐.
在每个EC度出现了不同的代谢模式,表明复杂的细胞毒性.

结论:

电子烟在肺上皮细胞中引发了显著的细胞代谢干扰.
对脂肪酸生物合成和氨基酸代谢等途径的不良影响是明显的.
需要进一步的研究,以了解EC诱导的代谢变化的长期健康后果.

关键词:

细胞毒性细胞毒性电子烟是一种电子烟.肺肺肺肺肺肺肺它的代谢物是代谢物.没有针对性的代谢组分.

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