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Updated: Jul 8, 2025

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原生质谱:针对蛋白质降解的洞察和机会

Louise M Sternicki1, Sally-Ann Poulsen1,2

  • 1Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland 4111, Australia.

Analytical chemistry
|December 13, 2023
PubMed
概括

原生质谱 (nMS) 揭示了向蛋白质降解 (TPD) 中的关键蛋白质相互作用. 这种生物物理方法独特地描述了E3结合酶,蛋白和PROTAC复合体,推动了TPD研究.

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
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