头骨底部的血细胞瘤:长期完整的响应与三模式治疗治疗
Meltem K Bolukbas1, Emine S Akovali1, Fatma Y Musri2
1Department of Radiation Oncology, Health Sciences University Erzurum Regional Training and Research Hospital, Caykara Street, Yakutiye-Erzurum, Turkey.
Indian journal of cancer
|December 13, 2023
概括
这项案例研究突出了成功的三模式治疗高度血管细胞瘤 (HPC),结合手术,放射治疗 (RT) 和sunitinib. 这种方法在罕见的内瘤病例中实现了完整的瘤回归和持续的反应.
科学领域:
- 神经瘤学神经瘤学
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 血皮细胞瘤 (HPC) 是一种罕见的内瘤,起源于齐默尔曼皮细胞,占这种瘤的不到1%.
- 高复发率需要放射治疗 (RT),但最佳时间和剂量仍然是不确定的.
- 骨底部瘤由于其位置而存在独特的外科手术和治疗挑战.
研究的目的:
- 报告一种罕见的高度血脉细胞瘤 (HPC) 病例,该病例使用三模式治疗方法治疗.
- 评估结合手术,术后放射治疗 (RT) 和辅助性苏尼提尼布在治疗HPC中的疗效.
- 强调三模式治疗对高度和具有挑战性的HPC病例的潜力.
主要方法:
- 一名39岁的患者患有大,高等级的头骨底部血液细胞瘤 (HPC) 接受了亚总切除.
- 术后放射治疗 (RT) 剂量为66 Gy.
- 在放射治疗后开始使用sunitinib辅助治疗.
主要成果:
- 在完成放射治疗 (RT) 后的三个月内,观察到血液血管细胞瘤 (HPC) 的完全回归.
- 患者在治疗后25个月内保持了完全的反应.
- 这一案例代表了一个罕见的例子,即时RT和辅助化疗与HPC的外科干预相结合.
结论:
- 一种包括手术,放射治疗 (RT) 和辅助化疗 (苏尼蒂尼布) 在内的三种治疗方法,可以在放射和化疗耐药血栓细胞瘤 (HPC) 中实现完整的反应.
- 这一策略对于患有高度,不可手术的瘤或接受亚整体切除的患者来说尤其重要.
- 进一步研究血脉皮细胞瘤 (HPC) 的三种疗法是有必要的,以建立最佳的治疗方案.
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