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Updated: Jun 27, 2026

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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对于患有伯基特淋巴瘤的儿童,利图西马布的最佳剂量

Shuang Huang1, Ling Jin1, Jing Yang1,2

  • 1Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing Key Laboratory of Pediatric Hematology Oncology, Key Laboratory of Major Disease in Children, Ministry of Education, Beijing, 100045, China.

Annals of hematology
|December 13, 2023
PubMed
概括

这项研究发现,与化疗相结合的四剂和六剂rituximab显著改善了儿童Burkitt无事件生存率.

关键词:
伯基特的淋巴瘤.中国儿童儿童中国儿童里图西马布 (Rituximab) 是一种药物.治疗结果的结果.

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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...