原发性甲状腺功能障碍的功能障碍与结石病,血清酸产物和副类激素水平升高有关
Mainak Banerjee1, Anish Kar1, Jan Ahamed2
1Department of Endocrinology, Institute of Postgraduate Medical Education and Research, Kolkata, 700020, India.
Endocrine
|December 13, 2023
概括
原发性甲状腺功能障碍 (PHPT) 与结石,高产物 (CaxP) 和偏激素 (PTH) 水平有关. 这些因素,而不仅仅是疾病严重程度,与PHPT患者的功能受损有关.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生化学
背景情况:
- 基线功能障碍是原发性偏甲状腺症 (PHPT) 死亡率的已知预测因素.
- 在PHPT中,功能衰竭的具体驱动因素,无论是仅仅是疾病严重程度还是额外的风险因素,仍在争论中.
- 了解这些关联对于管理PHPT和预防脏并发症至关重要.
研究的目的:
- 调查与功能障碍相关的临床和生化因素,定义为估计的膜过率 (eGFR) <60mL/min/m2.
- 为了区分疾病严重程度与PHPT相关功能障碍的其他风险因素的贡献.
主要方法:
- 一组112名PHPT患者被分为 (n=28) 和 (n=84) 患有功能障碍的组.
- 人口统计数据,传统的风险因素,PHPT表型和生化标志物在各组之间进行了比较.
- 用多重回归分析来确定功能障碍的显著预测因素.
主要成果:
- 功能障碍在男性中更为常见,并且与较高的血清,酸盐,性酸酶和完整的副激素 (PTH) 水平有关.
- 患有功能障碍的患者血红蛋白水平较低,结石病的发病率较高.
- 石病,血清-产物 (CaxP) 和PTH水平独立地与功能障碍相关 (p < 0.01).
- 对于PTH (>456 pg/mL) 和CaxP (>30.0 mg2/dL2) 的特定值有效地区分了功能障碍.
结论:
- 在PHPT中,功能障碍与结石病,CaxP和PTH水平升高有关,这表明与疾病过程本身有联系.
- 这些发现强调了监测PHPT患者脏健康的重要性.
- 在PHPT中对功能障碍的风险评估中应考虑血清CaxP.
相关概念视频
The Parathyroid Glands
2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
Nephrons
2.5K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.5K
Roles of Electrolytes: Calcium and Phosphate
288
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
The calcium concentration in blood plasma is primarily...
288
Skeleton and Calcium Homeostasis
4.6K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.6K
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Renal Drug Excretion: Tubular Secretion
192
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
192


