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Updated: Jul 8, 2025

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内神经元β-粉样蛋白通过对LONP1的影响损害了线粒体蛋白质稳定

Wenzhang Wang1, Xiaopin Ma1, Sabina Bhatta1

  • 1Department of Pathology, Case Western Reserve University, Cleveland, OH 44106.

Proceedings of the National Academy of Sciences of the United States of America
|December 13, 2023
PubMed
概括

阿尔茨海默病 (AD) 涉及线粒体功能障碍. 这项研究表明,由于Aβ42相互作用,LONP1蛋白酶活性降低导致线粒体蛋白质稳定缺陷和AD的认知衰退.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42这就是LONP1的意义.线粒体功能障碍 线粒体功能障碍蛋白质聚合物的蛋白质聚合物.

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