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用可生物降解聚合物支架进行冠状动脉干预后,急性冠状动脉综合征患者的长期结果

Manijeh Noori¹, Evald Høj Christiansen², Bent Raungaard³

¹Department of Cardiology, Odense University Hospital, Odense, Denmark.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

|December 13, 2023

概括

患有急性冠状动脉综合征 (ACS) 的患者在经皮冠状动脉干预后面临着更高的支架血栓形成风险. 然而,在ACS和非ACS患者中,Orsiro支架 (O-SES) 和Nobori支架 (N-BES) 之间的长期结果和目标病变失败率相似.

科学领域:

心脏病学心脏病学
干预心脏病学干预心脏病学
生物材料科学生物材料科学

背景情况:

患有急性冠状动脉综合征 (ACS) 的患者在皮肤冠状动脉干预 (PCI) 后可能会出现较差的结果,而不是那些没有 ACS 的患者.
这项研究研究了两种可生物降解的聚合物药物排泄支架的长期安全性和有效性,这些支架用于患有和没有ACS的患者.

研究的目的:

为了比较超薄支架 sirolimus 排泄的 Orsiro 支架 (O-SES) 和 biolimus 排泄的 Nobori 支架 (N-BES) 在患有和没有 ACS 的患者的 5 年疗效和安全性.
在PCI后5年评估目标病变衰竭 (TLF) 和明确的支架血栓发生率.

主要方法:

一个随机试验 (斯堪的纳维亚随机试验组织与临床结果VII) 在一个全新人群中比较O-SES和N-BES.
招募了2525名患者,其中1329人 (53%) 被诊断患有ACS,1196人 (47%) 没有ACS.
主要终点包括TLF (心脏死亡,目标病变MI或目标病变再血管化) 和5年内确定的支架血栓形成.

主要成果:

在5年的随访中,在患有ACS和没有ACS的患者 (12.3%与13.2%) 之间没有观察到TLF的显著差异.
患有ACS的患者表现出确定的支架血栓形成的风险增加 (2.3%对1.3%).
在ACS患者中,O-SES和N-BES之间的TLF率相似 (12.4%对12.3%),O-SES的初始支架血栓形成益处在5年后没有持续.

结论:

患有ACS的患者具有高风险的支架血栓形成不论使用的支架类型.
长期结果,特别是TLF,在5年后与ACS患者相比,可与O-SES或N-BES治疗.

关键词:

可生物降解的聚合物.生物质地质的生物质地质.冠状动脉支架 (英语:coronary stent) 是一种冠状动脉支架.心肌梗塞的心脏病发作这是西洛利斯 ( sirolimus).支架凝血症支架凝血症目标损伤失败的目标损伤失败目标病变的重血管化

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