美国青少年暴露于三甲和骨矿物质密度:一个横截面研究 (NHANES)
Yang Sun1,2, Yi-Xin Wang3, Chong Liu3
1Department of Otolaryngology-Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai 200233, China.
Environmental science & technology
|December 13, 2023
概括
血液中的三甲 (THM) 与青少年的骨矿物质密度 (BMD) 较低有关. 较高的THM水平,特别是含量的THM水平,与腰椎和全身减去头部BMDz分数的减少有关.
科学领域:
- 环境健康 环境健康
- 骨生物学 骨生物学 骨生物学
- 毒理学 毒理学 毒理学
背景情况:
- 三甲 (THM) 是饮用水中的消毒副产品.
- 之前的研究表明THM在动物和人类的骨中具有潜在的毒性.
- 青春期是骨发育和积累的一个关键时期.
研究的目的:
- 调查青少年血液和自来水THM度与骨矿物质密度 (BMD) 之间的关系.
- 检查特定的THM,包括甲 (TCM),二甲 (BDCM),二甲 (DBCM) 和甲 (TBM).
- 评估THM暴露与腰椎和全身减去头部 (TBLH) BMD之间的关系.
主要方法:
- 从国家健康和营养检查调查 (NHANES) 的数据分析.
- 血液和自来水中THM度的量化 (TCM,BDCM,DBCM,TBM).
- 测量腰椎和TBLH骨矿物密度 (BMD) 的测量.
- 调整回归模型来评估THM水平和BMD之间的关联.
主要成果:
- 血中化THM (TCM,BDCM,DBCM) 和总THM的2.7倍增加与腰椎下部BMDz-score相关.
- 同样,增加的血液BDCM,DBCM和化THMs与较低的TBLH BMDz分数相关.
- 龙头水THM度显示血液THM水平的预测能力低至中等;反向关联对DBCM和化THM (Br-THMs) 与TBLH BMD最强.
结论:
- 青少年接触THM,如血度所示,可能会对骨矿物质密度产生不利影响.
- 特定的THM如DBCM和Br-THM显示与TBLH BMD的反向关联.
- 需要进一步的研究,以了解THM骨毒性在骨发育过程中的机制.
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