在Heliox潜水到81米后,肺氧毒性呼吸标志物
Feiko Jm de Jong1,2,3, Paul Brinkman4, Thijs T Wingelaar1,2
1Royal Netherlands Navy Diving and Submarine Medical Centre, 1780 CA, Den Helder, The Netherlands.
Diving and hyperbaric medicine
|December 13, 2023
概括
海军潜水员在氧潜水时呼出与肺氧毒性 (POT) 相关的挥发性有机化合物 (VOC). 这些生物标志物出现在任何临床症状之前,这表明POT是在亚临床发展的.
科学领域:
- 高压医学的高压医学.
- 肺部生理学 肺部生理学
- 生物标志物发现发现
背景情况:
- 肺氧毒性 (POT) 是由于长时间暴露在高氧压下引起的.
- POT可能导致肺纤维化,最初的症状通常涉及气管不适.
- 之前的研究已经确定了在实验室环境中排出的挥发性有机化合物 (VOC) 作为潜在的POT生物标志物.
研究的目的:
- 为了调查海军潜水员在执行氧潜水后的呼气中的VOCs.
- 为了确定在现场环境中是否可以检测出POT的VOCs.
- 在现实潜水操作中评估POT生物标志物的亚临床存在.
主要方法:
- 从三名海军潜水员那里收集了呼吸样本,这些潜水员在氧潜水期间暴露在81米深的海水中.
- 使用有针对性的多变量分析来确定特定VOC的显著变化.
- 在潜水后4小时的采样期间,分析了呼出的呼吸.
主要成果:
- 鉴定出多德干,四度干,八,甲基环和丁酸盐的显著变化 (P = 0.004).
- 潜水员没有报告任何临床症状或呼吸道不适.
- 在没有主观POT症状的情况下检测到表明氧毒性的VOC.
结论:
- 在操作潜水期间,可以对POT生物标志物进行基于现场的呼吸采样.
- 呼出的VOC可以表明亚临床肺氧毒性.
- 需要进一步的研究来完善现场采样协议,并建立剂量反应关系.
相关概念视频
Pneumothorax-I
212
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
212
Acute Respiratory Failure-II
239
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
239
Hypoxia
1.1K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.1K
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
614
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
614
Acute Respiratory Failure-IV
159
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
159
Special considerations while measuring oxygen saturation
592
Assessing respiratory rate concurrently with pulse measurement is fundamental to patient care, providing valuable insights into the patient's respiratory function. The normal breathing rate for an adult usually falls within a normal range of 12 to 20 breaths per minute. Abnormal respiratory rates can signal underlying health conditions or the need for immediate intervention.
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is...
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is...
592


