中年身体活动的参与与晚年大脑健康有关
Meishan Ai1, Timothy P Morris2, Adrián Noriega de la Colina3
1Department of Psychology, Northeastern University, Boston, MA 02115, USA.
Neurobiology of aging
|December 13, 2023
概括
中年身体活动 (PA) 显示出对晚年大脑健康的潜在益处,特别是灰质结构和大脑连接,即使在患阿尔茨海默病高风险的人群中也是如此.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 中年身体活动 (PA) 对晚年认知和大脑健康的影响尚不清楚,研究结果不一致.
- 了解高风险人群中的这种关系对于制定有针对性的健康干预措施至关重要.
研究的目的:
- 调查中年PA与晚年认知,灰质特征和静止状态功能连接之间的关联.
- 为了检查老年人患阿尔茨海默病高风险的这些关联.
主要方法:
- 分析中年PA参与度的横截面研究.
- 使用神经成像技术评估晚年认知功能,灰色物质表面积和静止状态的功能连接.
- 专注于患阿尔茨海默病风险较高的老年人.
主要成果:
- 在中年PA和晚年认知功能之间没有发现有意义的直接关联,但这被晚年PA调节了.
- 增加中年中度至强烈的PA与左中额头回中较大的灰质表面积相关.
- 中年总PA与大脑区域的功能连接性发生变化有关,包括额叶皮质,带带运动区域,海马和小脑.
结论:
- 中年期的体力活动可能独立地有助于在以后的生活中保持大脑健康.
- 中年PA的特定类型和水平与明显的结构和功能大脑变化有关.
- 研究结果突出了中年PA的潜力,作为老年人群中神经退行性疾病风险的大脑健康的可修改因素.
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