13-14岁的大麻使用和神经认知表现:在青少年大脑认知发展 (ABCD) 研究中优化用头发毒理学评估
Natasha E Wade1, Alexander L Wallace1, Marilyn A Huestis2
1Department of Psychiatry, University of California, San Diego, USA.
Addictive behaviors
|December 13, 2023
概括
青少年使用大麻与较差的记忆力和认知功能有关. 将头发毒理与自我报告相结合,揭示了年轻大麻使用者的更多大脑行为关系.
科学领域:
- 神经科学是一个神经科学.
- 青少年发展 青少年发展
- 药物使用研究研究 药物使用研究
背景情况:
- 青春期是神经认知发育的关键时期.
- 大麻使用在青少年中普遍存在,根据方法学,检测率有所不同.
- 之前关于大麻和青少年大脑功能的研究已经产生了相互矛盾的结果.
研究的目的:
- 研究大麻在青春期早期使用的神经认知影响.
- 为了比较头发毒理学与自我报告在检测大麻相关的大脑行为关联方面的有效性.
- 为未来的纵向研究确定青少年大麻使用者的基线神经认知表现.
主要方法:
- 利用了青少年大脑认知发展 (ABCD) 研究的数据,包括头发样本和NIH工具箱认知电池.
- 使用LC-MS/MS和GC-MS/MS评估THC代谢物 (THCCOOH),THC和大麻二醇的头发样本.
- 在大麻使用 (CU) 组 (n=123) 和匹配的对照组 (n=123) 之间比较神经认知表现,控制社会人口统计.
主要成果:
- 与控制组相比,CU组在图像记忆方面得分较低 (p = .03).
- 在CU组中,较高的THCCOOH水平与较低的图片词汇和侧面抑制控制得分相关.
- 去年大麻使用与列表排序工作记忆和图片序列记忆有负面关联.
结论:
- 青少年大麻使用者在情节性记忆中表现出缺陷.
- 增加大麻使用与口头,抑制性,工作记忆和情节性记忆领域的表现较差有关.
- 综合的头发毒理学和自我报告数据提高了青少年大麻相关神经认知影响的识别.
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