新辅助化疗与胃癌中修改后的抗瘤微环境有关
Xiangkun Huan1, Kun Zou1, Peichan Zhang2
1Department of Surgical Oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
International immunopharmacology
|December 13, 2023
概括
新辅助化疗 (NAC) 将胃癌微环境转向抗瘤状态,改善患者的治疗结果. 关键的免疫细胞变化预测治疗反应和预后.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 新辅助化疗 (NAC) 是局部晚期胃癌 (GC) 的标准.
- NAC对瘤免疫微环境 (GCME) 的确切影响尚未完全理解.
研究的目的:
- 调查NAC对GCME内的免疫细胞群的影响.
- 为了将这些变化与治疗反应和患者预后相关联.
主要方法:
- 在配对的患者样本 (NAC前和后) 上的免疫组织化学和多重免疫光 (mIF).
- 对T细胞子集 (CD4+,CD8+,FOXP3+),与瘤相关的中性粒细胞 (TAN) 和与瘤相关的巨细胞 (TAMs,CD163+,CD86+) 的分析.
- 对免疫检查点标记物的评估 (PD1,PD-L1).
主要成果:
- NAC增加了CD8+:CD4+T细胞比率,M1:M2巨细胞比率,并减少了调节性T细胞 (T-regs),TAN和M2巨细胞.
- 在NAC后观察到PD1+ CD8+ T细胞,T-regs,PD-L1+ TAN和M2巨细胞的减少.
- 在NAC前的T-regs和M2巨细胞在响应者中较高;NAC后的比率预测了病理反应.
- 在NAC后增加的CD8+:CD4+和M1:M2巨细胞比率独立预测了良好的预后.
结论:
- NAC有效地将GCME重新编程成一种抗瘤的环境.
- 这些免疫调节见解可以指导个性化的GC免疫疗法策略.
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