周围和中央生物标志物与抗精神病原始第一发精神病的炎症相关:试点研究
Kristin S Cadenhead1, Heline Mirzakhanian1, Cristian Achim1
1University of California San Diego (UCSD), 9500 Gilman Dr, La Jolla, CA 92093-0810, United States of America.
Schizophrenia research
|December 13, 2023
概括
早期精神病中的外周炎症标志物与大脑化学和脑脊液炎症有关. 这表明神经炎症可能在精神病中发挥作用,可能识别出针对性治疗的亚型.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 在早期精神病中,可以观察到高水平的促炎分子.
- 外周和中枢神经系统 (CNS) 炎症生物标志物之间的联系仍然不清楚.
- 微质过活和随后的神经炎症可能会导致神经元亡和精神疾病中脑组织损失.
研究的目的:
- 调查在第一发精神病 (FEP) 中外围炎症生物标志物和中枢神经系统生物标志物之间的关联.
- 探索血炎性分子和大脑神经代谢物之间的相关性.
- 检查血和脑脊液 (CSF) 炎症分子之间的关系.
主要方法:
- 研究1:使用磁共振光谱 (1H-MRS) 评估13名先前未服用过抗精神病药物的FEP患者背部尾部神经代谢物.
- 研究2:在20名FEP患者中检查了血和CSF炎症分子之间的关系.
- 分析的重点是特定的炎症分子和神经化学标记物之间的相关性.
主要成果:
- 在第一项研究中,血化学因子 (MDC/CCL22) 和IL-10与背部尾部的谷氨酸和Glx水平呈正相关性.
- 在第二项研究中,几个血炎性分子 (MIP1β/CCL4,MCP1/CCL2,Eotaxin-1/CCL11,TNFα) 与相应的CSF分子 (MIP1β/CCL4,IL10,MCP1/CCL2,Fractalkine/CX3CL1) 有显著的相关性.
- 周围炎症生物标志物也与症状评级有关.
结论:
- 在早期精神病中血炎症生物标志物升高与神经化学变化和CSF炎症分子有关.
- 研究结果表明,在精神病中,外周炎症和中央神经炎症之间存在潜在的联系.
- 需要进一步研究将外围和中央生物标志物结合起来,以确定精神病的神经炎症亚型.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
95
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
95
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
677
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
677
Biological Causes of Schizophrenia
59
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
59


